We are pleased to launch PennAI – an accessible artificial intelligence system and open-source software developed by at the University of Pennsylvania’s Perelman School of Medicine by faculty, staff, and students from the Penn Institute for Biomedical Informatics (IBI). The components of PennAI include a human engine (i.e., the user); a user-friendly interface for interacting with the AI; a machine learning engine for data mining; a controller engine for launching jobs and keeping track of analytical results; a graph database for storing data and results (i.e., the memory); an AI engine for monitoring results and automatically launching or recommending new analyses; and a visualization engine to displaying results and analytical knowledge. This AI system provides a comprehensive set of integrated components for automated machine learning (AutoML), thus providing a data science assistant for generating useful results from large and complex data problems. More details can be found in our PennAI publications.